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SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
USERS' SCORE
Good
Based on 4 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Vitamin D3 (as Cholecalciferol) (from Lanolin)
125 mcg (5,000 IU)
625%
Top Medical Research Studies
9
Vitamin D3 inhibits lung cancer growth
Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.
Study highlights vitamin D3's importance
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
9
Vitamin D3 enhances lung cancer immunity
Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity.
Focused on lung cancer treatment
We explored the potential of aerosolized 1,25-dihydroxyvitamin D3, also known as vitamin D3, to enhance immune responses against lung cancer. This study focused on its ability to shift alveolar macrophages (AM) toward a more cancer-fighting role in the presence of lung metastases from tumors like MC-38 colon carcinoma and B16 melanoma.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Read More
8
Vitamin D3 inhibits lung cancer migration
1,25(OH) D inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming.
Significant findings on cancer treatment
We examined how vitamin D3, specifically in its active form 1,25-dihydroxy vitamin D3, influences lung cancer cells, particularly looking at Lewis lung cancer cells. Our research was guided by the question of whether vitamin D3 could affect both the movement of these cancer cells and their metabolism.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Read More
Most Useful Reviews
9.5
Significant recovery
Living in an area with little sun, my husband and I take vitamin D year-round. It has remarkably improved our immunity. I even gave it to my elderly in-laws during their lung cancer bout with coronavirus, leading to a rapid recovery within ten days.
Read More
8.8
Improved immune function
I used to take one vitamin D tablet daily without seeing much effect. After consulting a nutritionist, I increased my dose to three tablets (15,000 IU) daily. Now, I wake up feeling refreshed and less fatigued. Don't hesitate to increase your dose, as the sunlight here is insufficient.
Read More
8.8
Optimal vitamin levels
This high-quality NOW brand vitamin D keeps my levels excellent on blood tests. I take it daily and double the dosage on weekends, alongside vitamin K2. It’s fabulous for my immunity, especially as a cancer survivor; my doctor insists on maintaining high vitamin D levels.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 11 Researches
7.7
9
Vitamin D3 enhances lung cancer immunity
1α,25(OH)D reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells.
Relevant but effects partially obscured
We explored the potential role of vitamin D3 in lung cancer patients and its effects on the immune system, specifically focusing on T cells. The research involved 172 patients undergoing treatment for non-small cell lung cancer (NSCLC). These patients received standard chemotherapy and were then given varying doses of vitamin D3 for three weeks.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Our analysis revealed a significant connection between vitamin D levels and immune checkpoint receptors on T cells. Lower levels of vitamin D were associated with higher expressions of exhaustion markers like PD-1 and Tim-3, while higher vitamin D levels correlated with increased CD28 expression, an important marker for T cell activity.
When we looked into the mechanisms of how vitamin D3 works, we found that the active form of vitamin D promotes changes in T cells that help reduce their exhaustion. It does this by influencing specific genes and enhancing T cell function, leading to increased production of Th1 cytokines, which are crucial for effective immune responses against tumors.
Ultimately, we observed that vitamin D3 not only plays a role in improving the function of T cells but also seems to enhance their ability to combat tumor cells in lung cancer patients. This suggests that incorporating vitamin D3 into treatment regimens could potentially improve outcomes for those battling this disease.
Read More
9
Vitamin D3 inhibits lung cancer growth
Inhibition of lung cancer by vitamin D depends on downregulation of histidine-rich calcium-binding protein.
Study highlights vitamin D3's importance
We conducted a study to understand how vitamin D3 influences lung cancer, particularly focusing on a protein known as histidine-rich calcium-binding protein (HRC). Our research explored whether vitamin D3 could help lower HRC levels, given its crucial role in calcium balance, which is significant in cancer development.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
We measured the expression of HRC and the vitamin D receptor (VDR) in lung cancer tissues compared to normal and adjacent non-cancerous tissues. Using various lab techniques, we assessed how vitamin D3 affects lung cancer cells, including their growth, spread, and ability to undergo programmed cell death, known as apoptosis.
Our findings revealed that vitamin D3 does inhibit the expression of HRC, which in turn decreased the migration and proliferation of lung cancer cells. Additionally, we noted an increase in the number of cells undergoing apoptosis in response to vitamin D3 treatment. In our animal model, mice treated with a vitamin D3 formulation exhibited smaller tumors and fewer cancerous cells than those treated with a combination of vitamin D3 and HRC.
Overall, our study indicates that vitamin D3 plays a protective role against lung cancer by downregulating HRC, thus slowing tumor growth and promoting cancer cell death.
Read More
9
Vitamin D3 enhances lung cancer immunity
Aerosol 1,25-dihydroxyvitamin D3 supplementation: A strategy to boost anti-tumor innate immune activity.
Focused on lung cancer treatment
We explored the potential of aerosolized 1,25-dihydroxyvitamin D3, also known as vitamin D3, to enhance immune responses against lung cancer. This study focused on its ability to shift alveolar macrophages (AM) toward a more cancer-fighting role in the presence of lung metastases from tumors like MC-38 colon carcinoma and B16 melanoma.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
By treating AM with vitamin D3, we observed improved stimulation of natural killer (NK) cells, which are crucial for targeting tumor cells. Additionally, when administered in aerosol form directly to the lungs of healthy mouse models, vitamin D3 significantly reduced metastatic growth of cancer cells.
The effects were promising, as our findings indicated that the immune cells in the lungs exhibited greater activation markers and enhanced ability to kill tumor cells when exposed to this treatment. This suggests that targeting vitamin D3 supplementation directly to the lungs could be a novel and effective approach to harness local immunity in combating lung cancer.
Read More
8
Vitamin D3 inhibits lung cancer migration
1,25(OH) D inhibits Lewis lung cancer cell migration via NHE1-sensitive metabolic reprograming.
Significant findings on cancer treatment
We examined how vitamin D3, specifically in its active form 1,25-dihydroxy vitamin D3, influences lung cancer cells, particularly looking at Lewis lung cancer cells. Our research was guided by the question of whether vitamin D3 could affect both the movement of these cancer cells and their metabolism.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Through our analysis, we discovered that 1,25(OH)D treatment led to a significant reduction in the expression and activity of a protein known as Na/H exchanger isoform 1 (NHE1) in lung cancer cells. This protein is crucial for the cells' energy production, particularly through a process called glycolysis.
We observed that with the introduction of vitamin D3, not only was there a suppression of glycolytic enzyme activity—resulting in lower energy production from glucose—but also the overall balance between glycolysis and oxidative phosphorylation (OXPHOS) was shifted. This change helps to discourage cancer cell migration, which is a key factor in metastasis, or the spread of cancer to other parts of the body.
Additionally, our in vivo experiments supported these findings by showing inhibited tumor growth, further validating the potential role of vitamin D3 in combating lung cancer. Together, these results suggest that vitamin D3 could play a vital role in reprogramming cancer cell metabolism and preventing their movement, ultimately serving as a possible therapeutic strategy against lung cancer.
Read More
8
Vitamin D3 may lower lung cancer risk
Vitamin D Intake, Serum 25-Hydroxyvitamin-D (25(OH)D) Levels, and Cancer Risk: A Comprehensive Meta-Meta-Analysis Including Meta-Analyses of Randomized Controlled Trials and Observational Epidemiological Studies.
Study relevant to lung cancer
Our study focused on the effects of vitamin D3 on lung cancer, driven by the question of whether higher intake levels or increased serum levels of 25-hydroxyvitamin D could reduce cancer risk and mortality. We analyzed data from 35 different meta-analyses, which included a total of 59 reports, looking specifically at the relationship between vitamin D and lung cancer outcomes.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
The findings were intriguing. We observed that higher vitamin D intake and elevated serum levels were indeed associated with a lower risk of developing cancer. Specifically, when examining instances of lung cancer, we found that a significant reduction in incidence was linked to vitamin D consumption. The odds ratio for lung cancer incidence was reported at 0.88, suggesting that those who have sufficient vitamin D may experience a protective effect.
However, it is essential to note that when we looked exclusively at randomized controlled trials, the data did not show a significant connection between vitamin D intake and lung cancer risk. This suggests that while there may be promising observations in some studies, more rigorously designed research is necessary to draw definitive conclusions about vitamin D3 as an effective treatment for lung cancer.
Overall, while our exploration highlighted some potential benefits of vitamin D related to lung cancer, it's clear that careful consideration is needed when interpreting these results and their implications.
Read More
User Reviews
USERS' SCORE
Good
Based on 4 Reviews
8.6
9.5
Significant recovery
Living in an area with little sun, my husband and I take vitamin D year-round. It has remarkably improved our immunity. I even gave it to my elderly in-laws during their lung cancer bout with coronavirus, leading to a rapid recovery within ten days.
8.8
Improved immune function
I used to take one vitamin D tablet daily without seeing much effect. After consulting a nutritionist, I increased my dose to three tablets (15,000 IU) daily. Now, I wake up feeling refreshed and less fatigued. Don't hesitate to increase your dose, as the sunlight here is insufficient.
Read More
8.8
Optimal vitamin levels
This high-quality NOW brand vitamin D keeps my levels excellent on blood tests. I take it daily and double the dosage on weekends, alongside vitamin K2. It’s fabulous for my immunity, especially as a cancer survivor; my doctor insists on maintaining high vitamin D levels.
8.8
Tumour reduction
My doctor recommended this vitamin D3 for immunity. I also gave it to my father, who has lung cancer. It helped slightly shrink his tumour and improve his vitamin D levels. It’s effective for treating his condition.
